In this article we review some important software tools that have benefits for science teaching and we then describe ways in which the teacher has an important influence on the success of ICT activities in the classroom. Through examples of how such tools may be used to create new activities, we discuss some of the skills and teaching approaches needed to exploit their potential for learning. We look at a model of teacher development and suggest how the training materials developed by the ICT for Innovative Science Teachers Project (ICT for IST) might be used in future training courses to meet the challenge of a changing pedagogy with ICT.